Detalhe da pesquisa
1.
Domain-Specific Antibodies Reveal Differences in the Membrane Topologies of Apolipoprotein L1 in Serum and Podocytes.
J Am Soc Nephrol
; 31(9): 2065-2082, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32764138
2.
Tonic B cell antigen receptor signals supply an NF-kappaB substrate for prosurvival BLyS signaling.
Nat Immunol
; 9(12): 1379-87, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18978795
3.
Molecular characterization of human anti-hinge antibodies derived from single-cell cloning of normal human B cells.
J Biol Chem
; 293(3): 906-919, 2018 01 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29191832
4.
Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice.
J Biol Chem
; 292(9): 3900-3908, 2017 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28077575
5.
Trastuzumab triggers phagocytic killing of high HER2 cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages.
J Immunol
; 194(9): 4379-86, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25795760
6.
Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease.
Gastroenterology
; 149(6): 1564-1574.e3, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26170138
7.
An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations.
Methods
; 65(1): 114-26, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23872058
8.
Engineered protease-resistant antibodies with selectable cell-killing functions.
J Biol Chem
; 288(43): 30843-54, 2013 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23986451
9.
Structure and specificity of an antibody targeting a proteolytically cleaved IgG hinge.
Proteins
; 82(8): 1656-67, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24638881
10.
Tumor-associated macrophages promote invasion while retaining Fc-dependent anti-tumor function.
J Immunol
; 189(11): 5457-66, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23105143
11.
Multivalent human antibody-centyrin fusion protein to prevent and treat Staphylococcus aureus infections.
Cell Host Microbe
; 31(5): 751-765.e11, 2023 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098341
12.
A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.
Breast Cancer Res
; 14(4): R116, 2012 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22873525
13.
Avidity confers FcγR binding and immune effector function to aglycosylated immunoglobulin G1.
J Mol Recognit
; 25(3): 147-54, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22407978
14.
Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge.
Proc Natl Acad Sci U S A
; 106(42): 17864-9, 2009 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19815504
15.
The origins, specificity, and potential biological relevance of human anti-IgG hinge autoantibodies.
ScientificWorldJournal
; 11: 1153-67, 2011 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-21623461
16.
Human anti-IgG1 hinge autoantibodies reconstitute the effector functions of proteolytically inactivated IgGs.
J Immunol
; 181(5): 3183-92, 2008 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18713989
17.
Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
MAbs
; 11(6): 996-1011, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31156033
18.
19.
IgG Fc engineering to modulate antibody effector functions.
Protein Cell
; 9(1): 63-73, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28986820
20.
Immunoglobulin isotype knowledge and application to Fc engineering.
Curr Opin Immunol
; 40: 62-9, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27003675